PGE2 /EP4 antagonism enhances tumor chemosensitivity by inducing extracellular vesicle-mediated clearance of cancer stem cells

Cells expressing mesenchymal/basal phenotypes in tumors have been associated with stem cell properties, while cancer stem cells (CSCs) are often resistant to conventional chemotherapy. A team led by Dr. Hua-Jung Li from the Institute of Cellular and System Medicine, explored overcoming mesenchymal CSC resistance to chemotherapeutic agents with the goal…

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Dr. Feng-Huei Lin elected as Fellow of The American Institute for Medical and Biological Engineering (AIMBE)

Dr. Feng-Huei Lin, Director of Institute of Biomedical Engineering and Nanomedicine has been elected as Fellow of the prestigious American Institute for Medical and Biological Engineering (AIMBE) for his outstanding contributions in tissue engineering, regeneration medicine, drug/gene delivery advancement, and biomaterial development for disease treatment and prevention. Dr. Lin was…

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NHRI researchers report differentiation of MSCs from iPSCs in downregulation of c‐Myc and DNA replication pathways with immunomodulation toward CD4 and CD8 cells

A team led by Dr. B. Lin-Ju Yen from the Institute of Cellular and System Medicine, in collaboration with Dr. Ko-Jiunn Liu, National Institute of Cancer Research and Vice President Dr. Huey-Kang Sytwu, from National Institute of Infectious Diseases and Vaccinology, recently published their findings in Stem Cells (2018 Feb…

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