Association of pregnancy and mortality in women diagnosed with breast cancer: A nationwide population based study in Taiwan

In recent decades, the incidence rates of breast cancer have been increasing rapidly in Asian countries. Previous studies have shown that pregnancy has dual effects on breast cancer. However, with increasing incidence of breast cancer in young women and delayed childbearing, the incidence of pregnancy‐related breast cancer may have been…

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Effect of a point mutation in mprF on susceptibility to daptomycin, vancomycin, and oxacillin in an MRSA clinical strain

Daptomycin, a cyclic lipopeptide antibiotic, is one of the last-line agents for the treatment of certain severe multidrug-resistant Staphylococcus aureus infections, including those caused by methicillin-resistant S. aureus (MRSA). However, the exact mechanisms giving rise to daptomycin-non-susceptibility in S. aureus are not fully revealed but appear to involve diverse genetic…

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APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment

APBB2, amyloid beta (A4) precursor protein-binding family B member 2 has been reported to be associated with opioid dependence. Dr. Yu-Li Liu from the Center for Neuropsychiatric Research reported the first time that the genetic variants in the APBB2 gene were associated with use of amphetamine in opioid dependent patients…

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NHRI researchers find myeloid-derived macrophages and secreted HSP90α induce pancreatic ductal adenocarcinoma development

A team led by Dr. Tze-Sing Huang from the National Institute of Cancer Research, in collaboration with Taipei Veterans General Hospital, reported extracellular HSP90α (eHSP90α) can be potentially taken as a target to suppress pancreatic ductal adenocarcinoma (PDAC) pathogenesis besides myeloid cells. The team detected a significant elevation of serum…

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PGE2 /EP4 antagonism enhances tumor chemosensitivity by inducing extracellular vesicle-mediated clearance of cancer stem cells

Cells expressing mesenchymal/basal phenotypes in tumors have been associated with stem cell properties, while cancer stem cells (CSCs) are often resistant to conventional chemotherapy. A team led by Dr. Hua-Jung Li from the Institute of Cellular and System Medicine, explored overcoming mesenchymal CSC resistance to chemotherapeutic agents with the goal…

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NHRI researchers report differentiation of MSCs from iPSCs in downregulation of c‐Myc and DNA replication pathways with immunomodulation toward CD4 and CD8 cells

A team led by Dr. B. Lin-Ju Yen from the Institute of Cellular and System Medicine, in collaboration with Dr. Ko-Jiunn Liu, National Institute of Cancer Research and Vice President Dr. Huey-Kang Sytwu, from National Institute of Infectious Diseases and Vaccinology, recently published their findings in Stem Cells (2018 Feb…

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NHRI researchers demonstrate a distinct role of RPIA in colorectal cancer

The Institute of Molecular and Genomic Medicine has demonstrated a novel function of ribose-5-phosphate isomerase A (RPIA) in colorectal cancer formation. The team, led by Dr. Chiou-Hwa Yuh, in collaboration with Dr. Horng-Dar Wang, Institute of Biotechnology, National Tsing-Hua University recently published their findings in PLoS Biology  (2018 Jan 16;16(1):Article…

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