NHRI researchers find myeloid-derived macrophages and secreted HSP90α induce pancreatic ductal adenocarcinoma development

A team led by Dr. Tze-Sing Huang from the National Institute of Cancer Research, in collaboration with Taipei Veterans General Hospital, reported extracellular HSP90α (eHSP90α) can be potentially taken as a target to suppress pancreatic ductal adenocarcinoma (PDAC) pathogenesis besides myeloid cells. The team detected a significant elevation of serum…

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PGE2 /EP4 antagonism enhances tumor chemosensitivity by inducing extracellular vesicle-mediated clearance of cancer stem cells

Cells expressing mesenchymal/basal phenotypes in tumors have been associated with stem cell properties, while cancer stem cells (CSCs) are often resistant to conventional chemotherapy. A team led by Dr. Hua-Jung Li from the Institute of Cellular and System Medicine, explored overcoming mesenchymal CSC resistance to chemotherapeutic agents with the goal…

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NHRI researchers report differentiation of MSCs from iPSCs in downregulation of c‐Myc and DNA replication pathways with immunomodulation toward CD4 and CD8 cells

A team led by Dr. B. Lin-Ju Yen from the Institute of Cellular and System Medicine, in collaboration with Dr. Ko-Jiunn Liu, National Institute of Cancer Research and Vice President Dr. Huey-Kang Sytwu, from National Institute of Infectious Diseases and Vaccinology, recently published their findings in Stem Cells (2018 Feb…

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NHRI researchers demonstrate a distinct role of RPIA in colorectal cancer

The Institute of Molecular and Genomic Medicine has demonstrated a novel function of ribose-5-phosphate isomerase A (RPIA) in colorectal cancer formation. The team, led by Dr. Chiou-Hwa Yuh, in collaboration with Dr. Horng-Dar Wang, Institute of Biotechnology, National Tsing-Hua University recently published their findings in PLoS Biology  (2018 Jan 16;16(1):Article…

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