講題：THE USE OF WHOLE GENOME-RESEQUENCING
FOR DISCOVERY AND DESIGN
講者：Bernhard O. Palsson, Ph.D.
Galetti Professor, Dept. of Bioengineering, UCSD, U.S.A.
It has now become possible to re-sequence entire bacterial genomes with an accuracy that enables the identification of all mutations relative to a reference sequence. This capability is deployed to compare the genomic sequence of E. coli before and after an adaptation process during which a particular phenotypes is selected for. The genetic basis for bacterial adaptation can thus be determined. This capability is opening up new possibilities for discovery and design. It is likely that we can now study the genetic basis for infections disease, virulence and adaptation of human pathogens.
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《文：秘書室鄭慧貞整理；圖：Prof. Bernhard Palsson；錄影：鄭慧貞；影音整理：陳伊婷》