Cells expressing mesenchymal/basal phenotypes in tumors have been associated with stem cell properties, while cancer stem cells (CSCs) are often resistant to conventional chemotherapy. A team led by Dr. Hua-Jung Li from the Institute of Cellular and System Medicine, explored overcoming mesenchymal CSC resistance to chemotherapeutic agents with the goal…
A team led by Dr. B. Lin-Ju Yen from the Institute of Cellular and System Medicine, in collaboration with Dr. Ko-Jiunn Liu, National Institute of Cancer Research and Vice President Dr. Huey-Kang Sytwu, from National Institute of Infectious Diseases and Vaccinology, recently published their findings in Stem Cells (2018 Feb…
A recent review article published by Dr. Wen-Chun Hung, Deputy Director of National Institute of Cancer Research and his team in Molecular Cancer (2018 Feb 19;17(1):35), summarized current understanding of the role of pyruvate kinase M2-type (PKM2) in metabolic switch and gene regulation with emphasis on the recent progress of…
The Institute of Molecular and Genomic Medicine has demonstrated a novel function of ribose-5-phosphate isomerase A (RPIA) in colorectal cancer formation. The team, led by Dr. Chiou-Hwa Yuh, in collaboration with Dr. Horng-Dar Wang, Institute of Biotechnology, National Tsing-Hua University recently published their findings in PLoS Biology (2018 Jan 16;16(1):Article…
A team led by Dr. Feng-Huei Lin, Distinguished Investigator and Director of Institute of Biomedical Engineering and Nanomedicine, has developed an artificial tear solution combination for dry eye syndrome treatment which is more convenient and less harmful than the current treatment. One-third of elderly population aged 65 and above in…
